ASSISTANT PROFESSOR IN BIOCHEMISTRY – CAT NO 142/2018 – MEDICAL EDUCATION

FINAL ANSWER KEY
Question Paper Code: 14/2019/OL
Category Code: 142/2018
Exam: Assistant Professor Biochemistry
Medium of Question: English
Date of Test 23-05-2019
Department Medical Education
Alphacode A
Question1:-Dr. Gundert is associated with which of the following?
A:-London Mission Society
B:-Basel Evangelical Mission
C:-Church Mission Society
D:-Prussian Missionary
Correct Answer:- Option-B
Question2:-Who is the first editor of Swadesabhimani started by Vakkom Moulavi?
A:-K.Ramakrishnapillai
B:-C. Krishnapillai
C:-C.P. Govindapillai
D:-S. Padmanabha Panicker
Correct Answer:- Option-C
Question3:-In which conference did Sree Narayana Guru give the slogan “Not to argue and win but to know and make
known”?
A:-All Kerala Fraternity Conference at Aluva, 1921
B:-All Kerala Industrial Conference at Cannanore, 1909
C:-Superstition Eradication Conference at Kollam
D:-All Religious Conference at Aluva, 1924
Correct Answer:- Option-D
Question4:-Mokshapradipam is a work written by
A:-Vagbhadananda
B:-Kumaran Asan
C:-Brahmananda Sivayogi
D:-Sankaracharya
Correct Answer:- Option-C
Question5:-Name the great social reformer who is said to have inspired the Shanar agitation for social equality?
A:-Vaikunda Swamikal
B:-E.V. Ramaswami Naicker
C:-Poikayil Yohannan
D:-Thaikkattu Ayyavu
Correct Answer:- Option-A
Question6:-When was the Malayali Memorial submitted to the Travancore Maharaja?
A:-11 January 1891
B:-1 January 1891
C:-1 September 1891
D:-11 September 1891
Correct Answer:- Option-A
Question7:-Aphante Makal is a novel written by
A:-V.T. Bhattathiripad
B:-Lalithambika Antarjanam
C:-Bhavatratan Namboothiripadu
D:-Karur Nilakantapillai
Correct Answer:- Option-C
Question8:-The leader of the Akalis who led the Sikhs in the Vaikom Satyagraha?
A:-Gur Charan Singh
B:-Lala Lal Singh
C:-Lala Jai Singh
D:-Mr. Amar Singh
Correct Answer:- Option-B
Question9:-Karmavipakom is the autobiography of
A:-Karoor Nilakantan Namboothiripad
B:-V.T. Bhattathiripad
C:-M.C. Joseph
D:-Sahodaran Ayyappan
Correct Answer:-Question Cancelled
Question10:-The only Christian Satyagrahi who participated in the Vaikom Satyagraha and who was asked to quit the
movement by Mahatma Gandhi?
A:-Barister George Joseph
B:-M.O. Mathai
C:-Kandathil Varghese Mappilai
D:- Joseph Pulikkunnel
Correct Answer:- Option-A
Question11:-Mitavadi was started by
A:-C. Krishnan
B:-C. Kesavan
C:-Kunhiraman Nair
D:-T. Sivasankaran
Correct Answer:- Option-D
Question12:-Who is known as ‘Kesari’?
A:-C.V. Kunhiraman Nair
B:-E.M. Kovur
C:-M.R. Nair
D:-Vengayil Kunhiraman Nair
Correct Answer:- Option-D
Question13:-Who founded Malabar Economic Union?
A:-T.K. Madhavan
B:-Dr. P. Palpu
C:-Moorkkothu Kumaran
D:-Sahodaran Ayyappan
Correct Answer:- Option-B
Question14:-Jeevithasamaram is the autobiography of
A:-A.K. Gopalan
B:-C. Kesavan
C:-E.M.S. Namboodiripad
D:-K. Kelappan
Correct Answer:- Option-B
Question15:-Pattabakki is a drama written by
A:-P. Krishnapillai
B:-Kesava Dev
C:-Thakazhi
D:-K. Damodaran
Correct Answer:- Option-D
Question16:-Who is the founder of SEWA?
A:-Swarnakumari Devi
B:-Ramabhai Saraswathi
C:-Ela Bhatt
D:-Devi Chaudhurani
Correct Answer:- Option-C
Question17:-Protection of Women from Domestic Violence Act was passed in the year ?
A:-2005
B:-2006
C:-2011
D:-2012
Correct Answer:- Option-A
Question18:-ILO is situated at
A:-Rome
B:-Geneva
C:-Washington
D:-Paris
Correct Answer:- Option-B
Question19:-Article 32 of the Indian Constitution deals with
A:-Right to Property
B:-Directive Principles of State Policy
C:-Right to Constitutional Remedies
D:-Freedom of Religion
Correct Answer:- Option-C
Question20:-Who wrote the book A Passage to England?
A:-E.M. Foster
B:-Nirad C. Chaudhuri
C:-Kushwanth Singh
D:-R.K. Narayan
Correct Answer:- Option-B
Question21:-Which one of the following is NOT a constituent of lung surfactant?
A:-Dipalmitoyl lecithin
B:-Sphingomyelin
C:-Cholesterol
D:-Phosphatidyl glycerol
Correct Answer:-Question Cancelled
Question22:-Which one of the following molecular techniques is used to detect a specific RNA?
A:-Southern blot technique
B:-Northern blot technique
C:-Western blot technique
D:-In situ hybridization
Correct Answer:- Option-B
Question23:-Which one of the following features about genetic code is INCORRECT?
A:-Non-degenerate
B:-Non-ambiguous
C:-Non-overlapping
D:-Continuous
Correct Answer:- Option-A
Question24:-Which one of the following conditions results from defective alpha oxidation?
A:-Methyl malonic aciduria
B:-Glutaric aciduria
C:-Refsum’s disease
D:-Propionic acidemia
Correct Answer:- Option-C
Question25:-Which one of the following amino acids is purely ketogenic?
A:-Leucine
B:-Isoleucine
C:-Lysine
D:-Phenyl alanine
Correct Answer:- Option-A
Question26:-All the following conditions show low serum AFP level EXCEPT
A:-Down syndrome
B:-Anencephaly
C:-Trisomy 18
D:-Turners syndrome
Correct Answer:- Option-B
Question27:-All the following statements regarding glutathione are true EXCEPT
A:-It favours the absorption of neutral amino acids in the intestine
B:-It inactivates insulin
C:-It is an atypical tripeptide
D:-It plays an important role in free radical scavenging
Correct Answer:- Option-B
Question28:-Which one of the following is NOT a post-transcriptional modification?
A:-5′ capping
B:-Poly-A tailing
C:-Acetylation
D:-Methylation
Correct Answer:- Option-C
Question29:-Select the FALSE statement regarding phosphofructokinase 1.
A:-It is activated by AMP
B:-Fructose 2,6 bisphosphate inhibits this enzyme
C:-During starvation the synthesis of this enzyme is repressed
D:-Fructose 6 phosphate activates this enzyme
Correct Answer:- Option-B
Question30:-All the following statements regarding pentose phosphate pathway is correct EXCEPT
A:-Glucose-6-phosphate dehydrogenase is the rate limiting enzyme of the pathway
B:-In RBCs it is the only source of NADPH for free radical scavenging
C:-No ATP is produced in this pathway
D:-Glucose-6-phosphate dehydrogenase is inhibited by insulin
Correct Answer:- Option-D
Question31:-Which one of the following statements about glycogen metabolism is INCORRECT?
A:-Glucagon enhances glycogenolysis in muscle
B:-Epinephrine enhances glycogenolysis in liver and muscle
C:-Glycogenolysis in liver will lead to increase in blood glucose level
D:-Pyridoxal phosphate is essential for glycogenolysis in muscle
Correct Answer:- Option-A
Question32:-Regarding pancreatic lipase the INCORRECT statement is
A:-It is a glycoprotein
B:-It’s serum level is increased in renal insufficiency
C:-It has a specificity of 80-100% in diagnosing acute pancreatitis
D:-It’s serum level increases within 8 to 12 hours and reaches a peak by 48 hours after an acute attack of pancreatitis
Correct Answer:- Option-D
Question33:-Which is the soluble storage form of iron in tissues?
A:-Ferritin
B:-Transferrin
C:-Hemosiderin
D:-Haptoglobin
Correct Answer:- Option-A
Question34:-Black liver jaundice is seen in
A:-Dubin Johnson syndrome
B:-Rotor syndrome
C:-Glibert’s disease
D:-Crigler-Najjar syndrome
Correct Answer:- Option-A
Question35:-Select the neurotransmitter synthesized from tyrosine
A:-GABA
B:-Melatonin
C:-Dopamine
D:-Serotonin
Correct Answer:- Option-C
Question36:-Which of the following is used for staining DNA fragments in electrophoresis?
A:-Coomasssie Brilliant Blue
B:-Nitrotetrazolium Blue
C:-Silver Nitrate
D:-Ethidium Bromide
Correct Answer:- Option-D
Question37:-Which liver enzyme is best for detecting biliary obstruction?
A:-Alanine amino transferase
B:-Alkaline phosphatase
C:-Nucleotide phosphatase
D:-Gamma glutamyl transferase
Correct Answer:- Option-C
Question38:-Which of the following statement is NOT true regarding oncogenes?
A:-Mutation in one of the two alleles is sufficient to produce oncogenic effects
B:-Oncogenic effect is due to gain of function of a protein that stimulates cell growth and proliferation
C:-Mutations in oncogenes may be present in somatic or germ cells
D:-Usually do not show tissue preference with respect to the type of cancers in which they are found
Correct Answer:- Option-C
Question39:-All the following are multienzyme complexes EXCEPT
A:-Pyruvate carboxylase
B:-Alpha keto dehydrogenase
C:-Acetyl Co A carboxylase
D:-Pyruvate kinase
Correct Answer:- Option-D
Question40:-Which of the following is an example for non-competitive inhibition?
A:-Allopurinol inhibits xanthine oxidase
B:-Fluoride inhibits enolase
C:-5-fluorouracil inhibits thymidylate synthase
D:-Lovastatin inhibits HMG Co A reductase
Correct Answer:- Option-B
Question41:-Which of the following is NOT a serine protease?
A:-Trypsin
B:-Thrombin
C:-Carbonic anhydrase
D:-Chymotrypsin
Correct Answer:- Option-C
Question42:-Which is the best marker of ventricular dysfunction?
A:-CK-MB
B:-Cardiac troponin I
C:-Brain natriuretic peptide
D:-Myoglobin
Correct Answer:- Option-C
Question43:-Select the glucose transporter that is insulin dependent.
A:-GLUT 2
B:-GLUT 4
C:-GLUT 5
D:-SGLT 1
Correct Answer:- Option-B
Question44:-Which of the following statement is FALSE regarding mitochondrial DNA?
A:-Majority of the mitochondrial proteins are coded by mitochondrial DNA
B:-Mitochondrial DNA have high mutation rate than nuclear DNA
C:-Mitochondrial cytopathies show a maternal non-mendelian inheritance
D:-Mitochondrial DNA shows heteroplasmy
Correct Answer:- Option-A
Question45:-Regarding p53 all the statements are true EXCEPT
A:-Is a DNA binding transcription factor
B:-Induces the genes that induce apoptosis
C:-Is the least mutated genes in human cancers
D:-Is a tumor suppressor gene
Correct Answer:- Option-C
Question46:-Regarding apoptosis, select the FALSE statement.
A:-Cytochrome c is an inducer of apoptosis
B:-bcl-2 is an apoptosis protecting gene
C:-Caspase 3 is the initiator caspase of apoptosis
D:-Ceramide is an important regulator of apoptosis
Correct Answer:- Option-C
Question47:-Which one of the following is a chain breaking anti-oxidant?
A:-Catalase
B:-Vitamin E
C:-Glutathione peroxidase
D:-Ethylenediaminetetraacetate
Correct Answer:- Option-B
Question48:-Select the enzyme that is NOT present in the liver.
A:-HMG Co A lyase
B:-HMG Co A synthase
C:-Thiolase
D:-Thiophorase
Correct Answer:- Option-D
Question49:-Linoleic acid is considered to be a nutritionally essential fatty acid in humans BECAUSE
A:-It is an omega 3 fatty acid
B:-In humans double bond cannot be introduced at Δ`^6` position
C:-In humans double bond cannot be introduced at Δ`^9` position
D:-In humans double bond cannot be introduced at Δ`^12` position
Correct Answer:- Option-D
Question50:-Regarding insulin which of the following statement is FALSE?
A:-Inhibits hormone sensitive lipase
B:-Inhibits acetyl Co A carboxylase
C:-Activates glycerol phosphate acyl transferase
D:-Activates pyruvate dehydrogenase
Correct Answer:- Option-B
Question51:-Which one of the following is NOT a cause of fatty liver?
A:-Protein deficiency
B:-Orotic acid deficiency
C:-Pantothenic acid deficiency
D:-Linoleic acid deficiency
Correct Answer:- Option-B
Question52:-Niemann-Pick disease is due to the deficiency of
A:-Hexosaminidase A
B:-Hexosaminidase A and B
C:-Beta glucosidase
D:-Sphingomyelinase
Correct Answer:- Option-D
Question53:-All the following statements are true regarding water EXCEPT
A:-Water molecules form dipoles
B:-The angle between two hydrogen atoms in water molecule is 105°
C:-Has low dielectric constant
D:-Is an excellent nucleophile
Correct Answer:- Option-C
Question54:-Which of the following can be a cause of Normal Anion Gap Metabolic Acidosis?
A:-Organic aciduria
B:-Salicylate poisoning
C:-Acetazolamide therapy
D:-Lactic acidosis
Correct Answer:- Option-C
Question55:-All the following statements regarding pKa are true EXCEPT
A:-At pKa the ratio of salt to acid in a buffer is 2:1
B:-At pKa the buffer has maximum buffering capacity
C:-pKa of an acid is the pH at which the acid is half ionized
D:-Weak acids have high pKa
Correct Answer:- Option-A
Question56:-Which one of the following test is used to detect CSF globulins?
A:-Heller’s test
B:-Pandy’s test
C:-Oliver’s test
D:-Pettenkoffer’s test
Correct Answer:- Option-B
Question57:-Of the following which hypotheses claims that there is an association between the predictor and outcome
variables?
A:-Alternative hypotheses
B:-Null hypotheses
C:-Statistical hypotheses
D:-Composite hypotheses
Correct Answer:- Option-A
Question58:-If mean is 25 and standard deviation is 5, then coefficient of variation is
A:-5%
B:-20%
C:-25%
D:-75%
Correct Answer:- Option-B
Question59:-Which of the following is the best test based on the ROC curve?
A:-Area under the curve is more than 0.9
B:-Area under the curve is 0.5
C:-Area under the curve is less than 0.1
D:-Area under the curve is less than 0.01
Correct Answer:- Option-A
Question60:-Which one of the following statements is NOT TRUE regarding telomerase?
A:-It’s activity is increased in cancer
B:-Loss of telomerase activity leads to aging
C:-It is a ribozyme
D:-It has reverse transcriptase activity
Correct Answer:- Option-C
Question61:-Which one of the following diseases results from defective nucleotide excision repair mechanism?
A:-Xeroderma Pigmentosum
B:-Hereditary Polyposis Colon Cancer
C:-Fanconi’s Anemia
D:-Bloom’s Syndrome
Correct Answer:- Option-A
Question62:-Which one of the following is NOT true regarding IgM?
A:-Do not fix complement
B:-Antigen receptor is on the surface of B cells
C:-Do not cross the placenta
D:-Involved in primary response
Correct Answer:- Option-A
Question63:-Which amino acid is relatively absent in alpha helices?
A:-Glycine
B:-Valine
C:-Tryptophan
D:-Arginine
Correct Answer:- Option-A
Question64:-Which one of the following diseases is due to defective collagen synthesis?
A:-Leukocyte adhesion deficiency II
B:-Ehlers-Danlos syndrome
C:-Paroxysmal nocturnal hemoglobinuria
D:-I-cell disease
Correct Answer:- Option-B
Question65:-Which of the following vitamins provide the cofactor for transketolase reaction?
A:-Vitamin `”B_6″`
B:-Niacin
C:-Thiamine
D:-Riboflavin
Correct Answer:- Option-C
Question66:-Which one of the following histone amino acid is typically acetylated?
A:-Lysine
B:-Arginine
C:-Histidine
D:-Leucine
Correct Answer:- Option-A
Question67:-Vitamin C is not synthesized in humans due to the deficiency of ____________.
A:-L-Xylulose dehydrogenase
B:-L-Gulonolactone oxidase
C:-L-Gulonate oxidase
D:-D-Glucuronate reductase
Correct Answer:- Option-B
Question68:-In the human body isoniazid is detoxified by _____________.
A:-Acetylation
B:-Methylation
C:-Conjugation with sulphate
D:-Conjugation with glycine
Correct Answer:- Option-A
Question69:-During protein synthesis which amino acid is incorporated first in eukaryotes?
A:-N-formyl methionine
B:-Methionine
C:-Phenyl alanine
D:-Glutamine
Correct Answer:- Option-B
Question70:-Tetany is found in all the following conditions EXCEPT
A:-Hypoparathyroidism
B:-Renal insufficiency
C:-Vitamin D deficiency
D:-Metabolic alkalosis
Correct Answer:-Question Cancelled
Question71:-The reference interval for plasma osmolality is
A:-150 to 175 mOsmol/Kg
B:-300 to 325 mOsmol/L
C:-275 to 300 mOsmol/Kg
D:-350 to 375 mOsmol/L
Correct Answer:- Option-C
Question72:-Which one of the following is a marker of bone resorption?
A:-Procollagen typeI N-terminal propeptide
B:-C-telopeptide
C:-Osteocalcin
D:-Bone alkaline phosphatase
Correct Answer:- Option-B
Question73:-Specific dynamic action for protein is
A:-5%
B:-15%
C:-30%
D:-55%
Correct Answer:- Option-C
Question74:-Which of the following is NOT a constituent of human glycoproteins?
A:-Glucose
B:-Fucose
C:-Xylose
D:-Sucrose
Correct Answer:- Option-D
Question75:-In which of the following condition CSF glucose is normal?
A:-Bacterial meningitis
B:-Tuberculous meningitis
C:-Viral meningitis
D:-Brain tumor
Correct Answer:- Option-C
Question76:-Which one of the following statements is FALSE regarding nitric oxide?
A:-Asparagine is the precursor of nitric oxide
B:-Is a potent vasodilator
C:-Depresses platelet function
D:-Results in refractory hypotension in septicemia
Correct Answer:- Option-A
Question77:-Westgard multirule `4_{1s}` is sensitive to which type of analytical error?
A:-Systematic error
B:-Imprecision error
C:-Random error
D:-Standardization error
Correct Answer:- Option-A
Question78:-Which is the optical technique that measures the emitted light by a species that has absorbed exciting
radiation from an outside source?
A:-Spectrophotometry
B:-Reflectance photometry
C:-Fluorometry
D:-Nephelometry
Correct Answer:- Option-C
Question79:-In which condition is a decrease in serum albumin and an increase in alpha2-macroglobulin seen?
A:-Cirrhosis
B:-Inflammation
C:-Multiple myeloma
D:-Nephrotic syndrome
Correct Answer:- Option-D
Question80:-The most common biological recognition element used in a biosensor is
A:-Antigen
B:-Antibody
C:-Enzyme
D:-Hormone
Correct Answer:- Option-C
Question81:-Which of the following is the marker enzyme of microsomes?
A:-Cathepsin
B:-Galactosyl transferase
C:-Catalase
D:-Glucose-6-phosphatase
Correct Answer:- Option-D
Question82:-Hill equation explains
A:-Bi-bi reaction of enzymes
B:-Co-operative binding of enzymes
C:-Ping-pong mechanism of enzymes
D:-Suicidal inhibition of enzymes
Correct Answer:- Option-B
Question83:-Select the glycosaminoglycan which does not contain uronic acid.
A:-Keratan sulfate
B:-Chondroitin sulfate
C:-Dermatan sulfate
D:-Hyaluronic acid
Correct Answer:- Option-A
Question84:-Which of the following is NOT true regarding 2,3-BPG?
A:-Stabilizes the T structure of hemoglobin
B:-`”CO_2″` increases the synthesis of 2,3-BPG
C:-2,3-BPG binds strongly to HbF than HbA
D:-At high altitude the synthesis of 2,3-BPG is increased
Correct Answer:- Option-C
Question85:-Which of the following test is NOT used for the diagnosis of secondary adrenal insufficiency?
A:-Dexamethasone suppression test
B:-Cosyntropin test
C:-Overnight metyrapone test
D:-Insulin tolerance test
Correct Answer:- Option-A
Question86:-All the following hormones bind to cell surface receptors EXCEPT
A:-Insulin
B:-Substance P
C:-Thyroid hormone
D:-Glucagon
Correct Answer:- Option-C
Question87:-Which of the following hormone is NOT stored in the cells?
A:-Parathormone
B:-Aldosterone
C:-Insulin
D:-Adrenalin
Correct Answer:- Option-B
Question88:-Select the enzyme that is deficient in classical homocystinuria.
A:-Adenosine homocysteinase
B:-Homocysteine methyl transferase
C:-Cystathionine beta synthase
D:-Cystathionase
Correct Answer:- Option-C
Question89:-Which one of the following hormone is appetite suppressant?
A:-Leptin
B:-Ghrelin
C:-Glucagon
D:-Rennin
Correct Answer:- Option-A
Question90:-Which of the following is NOT a high energy compound?
A:-Creatine phosphate
B:-1,3-bisphosphoglycerate
C:-Glucose-6-phosphate
D:-Carbamoyl phosphate
Correct Answer:- Option-C
Question91:-Which of the following is an excellent GFR marker?
A:-Creatinine clearance
B:-Cystatin C
C:-Tamm Horsfall glycoprotein
D:-Inulin clearance
Correct Answer:- Option-D
Question92:-Which one of the following enzyme catalyzes a substrate level phosphorylation reaction?
A:-Phosphofructokinase
B:-Glucokinase
C:-Succinate thiokinase
D:-Succinate dehydrogenase
Correct Answer:- Option-C
Question93:-Which one of the following is a selenium containing enzyme?
A:-5′ deiodinase
B:-Thyroperoxidase
C:-Xanthine oxidase
D:-Glutamate dehydrogenase
Correct Answer:- Option-A
Question94:-Select the enzyme that is deficient in Lesch-Nyhan syndrome
A:-Phosphoribosyl amidotransferase
B:-Hypoxanthine guanine phosphoribosyl transferase
C:-Adenine phosphoribosyl transferase
D:-Phosphoribosyl pyrophosphate synthase
Correct Answer:- Option-B
Question95:-Cataract in galactosemia is due to accumulation of
A:-Dulcitol in lens
B:-Sorbitol in lens
C:-Mannitol in lens
D:-Iduronic acid in lens
Correct Answer:- Option-A
Question96:-Which one of the following apoproteins is present in LDL?
A:-Apo B-48
B:-Apo B-100
C:-Apo E
D:-Apo C
Correct Answer:- Option-B
Question97:-Which one of the following statements is FALSE regarding tRNA?
A:-Amino acid is attached to the 5′ CCA sequence
B:-DHU arm serves as the recognition site for the enzyme which adds the amino acid
C:-Anticodon arm recognizes the triplet nucleotide codon present in m RNA
D:-It contains the unusual amino acid hypoxanthine
Correct Answer:-Question Cancelled
Question98:-All the following are autosomal recessive diseases EXCEPT
A:-Albinism
B:-Sickle cell anemia
C:-Chondrodystrophy
D:-Phenyl ketonuria
Correct Answer:- Option-C
Question99:-Which one of the following is NOT a substrate for gluconeogenesis?
A:-Glycerol
B:-Propionyl CoA
C:-Even chain fatty acids
D:-Lactate
Correct Answer:- Option-C
Question100:-All the following are features of kwashiorkor EXCEPT
A:-Lethargic and apathetic
B:-Presence of anorexia
C:-Crazy pavement dermatitis
D:-Serum albumin 2 to 3 g/dl
Correct Answer:- Option-D