Assistant Professor in Biochemistry – Medical Education
FINAL ANSWER KEY
Question Paper Code: 62/2022/OL
Category Code: 004/2021
Exam: Assistant Professor in Biochemistry
Date of Test 11-08-2022
Department Medical Education
Alphacode A
Question1:-Which of the following statements is/are correct about RAST?
(i) It measures IgE antibodies in the serum
(ii) It is scored from 0 to 6
(iii) It is the same as the skin prick test
A:-Only (i)
B:-Only (i) and (ii)
C:-Only (ii)
D:-All of the above (i), (ii) and (iii)
Correct Answer:- Option-B
Question2:-A solution with pH 4 is _____________ times more acidic than a solution with pH 6
A:-2
B:-200
C:-10
D:-100
Correct Answer:- Option-D
Question3:-Which of the following drugs is not an enzyme inhibitor?
A:-Erythromycin
B:-Pencillin
C:-siRNA
D:-Sulfanilamide
Correct Answer:- Option-C
Question4:-Identify the protein that matches with the following descriptions:
(i) Fibrous protein
(ii) Composed of three chains
(iii) Associated with Ehlers-Danlos Syndrome
A:-Collagen
B:-Hyaluronic acid
C:-Elastin
D:-Keratin
Correct Answer:- Option-A
Question5:-Enzyme activity is measured based on the intensity of emitted light in _________ method
A:-Colorimetry
B:-Spectrophotometry
C:-Luminiscence
D:-Polarimetry
Correct Answer:- Option-C
Question6:-Pick the group of non-polar aminoacids
A:-Alanine, Leucine, Serine, Threonine
B:-Alanine, Leucine, Lysine, Histidine
C:-Alanine, Leucine, Lysine, Arginine
D:-Alanine, Leucine, Isoleucine, Methionine
Correct Answer:- Option-D
Question7:-Which of he following serves the purpose of locating the radioactive emissions in the process of autoradiography?
A:-Scintillation counter
B:-Photographic Emulsion
C:-Geiger Muller Counter
D:-Illumination screen
Correct Answer:- Option-B
Question8:-Which organelle does not contain nucleic acid?
A:-Ribosome
B:-Mitochondria
C:-Golgi Body
D:-Chloroplast
Correct Answer:- Option-C
Question9:-The plasma protein that is involved in copper homeostasis is ________
A:-Ceruloplasmin
B:-Albumin
C:-Immunoglobulin
D:-Haptoglobin
Correct Answer:-Question Cancelled
Question10:-Which technique/s can be used for the analysis of nucleic acids?
(i) PAGE
(ii) Northern Blotting
(iii) SDS PAGE
(iv) Southern Blotting
A:-All of the above (i), (ii), (iii) and (iv)
B:-Only (i) and (iii)
C:-Only (i) and (iv)
D:-Only (i), (ii) and (iv)
Correct Answer:- Option-D
Question11:-Identify the class of antibody with the bighest avidity for antigens:
A:-IgA
B:-IgM
C:-IgG
D:-IgE
Correct Answer:- Option-B
Question12:-A buffer solution contain 0.36 M sodium acetate (CH3COONa) and 0.036 M acetic acid (CH3COOH),pKa=4.8. What is the pH of this buffer solution?
A:-0
B:-4.8
C:-5.8
D:-7
Correct Answer:- Option-C
Question13:-Which kind of shift is associated with uv absorption of DNA that is denatured?
A:-Blue shift
B:-Bathochromic shift
C:-Hyperchromic shift
D:-Hypochromic shift
Correct Answer:- Option-C
Question14:-Match the following correctly:
(i) Oxidoreductase (a) Fumarase
(ii) Hydrolase (b) Aminoacyl tRNA Synthase
(iii) Lyase (c) Urease
(iv) Ligase (d) Catalase
A:-(i)-(b), (ii)-(c), (iii)-(a), (iv)-(d)
B:-(i)-(d), (ii)-(c), (iii)-(a), (iv)-(b)
C:-(i)-(a), (ii)-(c), (iii)-(b), (iv)-(d)
D:-(i)-(a), (ii)-(c), (iii)-(d), (iv)-(b)
Correct Answer:- Option-B
Question15:-The aminoacid that cannot be found in alpha-helix structure of proteins is _________
A:-Proline
B:-Glycine
C:-Histidine
D:-Lysine
Correct Answer:-Question Cancelled
Question16:-Which term represents the number of substrate molecules that can be converted to product by a single enzyme molecule per unit time?
A:-Specificity
B:-Catalysis
C:-Specific activity
D:-Turnover number
Correct Answer:- Option-D
Question17:-Which of the following is used to bombard the sample in Mass spectrometry?
A:-Proton
B:-Neutrons
C:-Electrons
D:-Gamma rays
Correct Answer:- Option-C
Question18:-The proteins bound to ion exchange resins can be displaced by altering the ____________
A:-Volume of eluent buffer
B:-Ionic strength of eluent buffer
C:-Volume of column
D:-Temperature of eluent buffer
Correct Answer:- Option-B
Question19:-Pick the incorrect statement
A:-Rhodopsin is an intrinsic protein
B:-Transmembrane proteins are integral membrane proteins
C:-Extrinsic proteins are also called peripheral proteins
D:-NADH dehydrogenase is an extrinsic protein
Correct Answer:- Option-A
Question20:-Which of the following diseases is associated with an elevated value of serum Creatine kinase-3 (CK3)?
A:-Brain Ischemia
B:-Kidney Damage
C:-Alcoholic Cirrhosis
D:-Muscular Dystrophy
Correct Answer:- Option-D
Question21:-Serum free fatty acids are found in combination with _________
A:-Globin
B:-Globulin
C:-Albumin
D:-Fibrinogen
Correct Answer:- Option-C
Question22:-All N-linked oligosaccharides have _______
A:-Pentasaccharide core
B:-Monosaccharide core
C:-Disaccharide core
D:-Trisaccharide core
Correct Answer:- Option-A
Question23:-Hemoglobin containing two mutant β-globin chain (Hbsβ) moves slowly towards anode during electrophoresis is due to the presence of ____________
A:-Leucine
B:-Isoleucine
C:-Valine
D:-Alanine
Correct Answer:- Option-C
Question24:-All the monosaccharides contain one or more chiral carbon atoms except
A:-Dihydroxyacetone
B:-Glyceraldehyde
C:-Glucose
D:-Fructose
Correct Answer:- Option-A
Question25:-Lipids have ____ specific gravities than water
A:-More
B:-Less
C:-Zero
D:-Equal
Correct Answer:- Option-B
Question26:-Chemical name of Guanine is
A:-2-amino, 6-oxypurine
B:-2-amino, 5-oxypurine
C:-2-amino, 7-oxypurine
D:-3-amino, 6-oxypurine
Correct Answer:- Option-A
Question27:-Number of base pairs per one complete turn of DNA double helix are:
A:-12
B:-10
C:-11
D:-09
Correct Answer:- Option-B
Question28:-A drug _____ inhibits protein synthesis in both prokaryotes and eukaryotes
A:-Chloramphenicol
B:-Cycloheximide
C:-Puromycin
D:-Tetracycline
Correct Answer:- Option-C
Question29:-Prokaryotic transcription start regions are called as
A:-Enhancers
B:-Operators
C:-Promoters
D:-Inducers
Correct Answer:- Option-C
Question30:-Pribnow-Schaller box has a sequence of _________
A:-TATAAT
B:-ATTATA
C:-TAAATT
D:-ATTTAA
Correct Answer:- Option-A
Question31:-The Hypothesis is used to make _____
A:-A point
B:-Predictions
C:-Test
D:-Conclusion
Correct Answer:-Question Cancelled
Question32:-Non-probability is also known as ________
A:-Simple random sampling
B:-Systematic sampling
C:-Stratified sampling
D:-Deliberate sampling
Correct Answer:- Option-D
Question33:-Precision is the closeness of a ________
A:-repeated measurements
B:-reported measurements
C:-accurate measurements
D:-Largest measurements
Correct Answer:- Option-A
Question34:-The expression of probability density function whose values range from zero to positive infinity is _______
A:-Chi-square distribution
B:-Poisson distribution
C:-Binomial distribution
D:-Frequency distribution
Correct Answer:- Option-A
Question35:-𝑋2
with n-1 degrees of freedom equivalent to __________
A:-(n-1) 𝑠2
𝜎2
B:-(n-1) 𝑠2
𝜎3
C:-(n-1) 𝑠2
𝜎1
D:-(n-1) 𝑠1
𝜎2
Correct Answer:- Option-A
Question36:-Coefficient of variation is the measure of ratio of _____ stated as a percentage
A:-mean to the standard deviation
B:-standard deviation to the median
C:-median to the standard deviation
D:-standard deviation to the mean
Correct Answer:- Option-D
Question37:-The term “biological reference interval” that deemed normal for a healthy person approved by _________
A:-ISO 15188
B:-ISO 15189
C:-ISO 15187
D:-ISO 15289
Correct Answer:- Option-B
Question38:-Reference value of serum creatinine in adult male would be ____________
A:-0.9-1.2 mg/dL
B:-0.6-0.9 mg/dL
C:-1.2-1.5 mg/dL
D:-0.7-1.0 mg/dL
Correct Answer:-Question Cancelled
Question39:-F test result is obtained by calculating the _____
A:-Between treatment square dividend by residual mean square
B:-Residual mean square divided by Between treatment mean square
C:-Between treatment square divided by residual square
D:-Between treatment mean square divided by residual mean square
Correct Answer:- Option-D
Question40:-The nonparametric method used to compare a single sample with some hypothesized value is ______________
A:-Mean
B:-Standard deviation
C:-Variance
D:-A sign test
Correct Answer:- Option-D
Question41:-Which of the following statements regarding Basal Metabolic Rate is incorrect?
A:-It is the minimum amount of energy required to sustain vital functions during physical rest
B:-It is the minimum amount of energy required to sustain vital functions during mental rest
C:-It is the minimum amount of energy required to sustain vital functions during sleep
D:-Basal Metabolic rate is lower than Resting Metabolic Rate
Correct Answer:- Option-C
Question42:-Which of the following is an appetite suppressant?
A:-Neuropeptide Y
B:-Serotonin
C:-Ghrelin
D:-Melanin
Correct Answer:- Option-B
Question43:-Select the false statement regarding Carcino Embryonic Antigen
A:-Its plasma level increases with smoking
B:-Useful for diagnosing localized breast cancer
C:-Is elevated in 70% of colorectal cancer
D:-Helpful in diagnosing non-small cell lung carcinoma
Correct Answer:- Option-B
Question44:-Which of the following is an oncosuppresser gene?
A:-c-fos
B:-bcl 2
C:-Ras
D:-p21
Correct Answer:- Option-A
Question45:-Which of the following vitamin do not have specific role in bone formation?
A:-Pyridoxal phosphate
B:-Vitamin K
C:-Vitamin D
D:-Vitamin C
Correct Answer:- Option-A
Question46:-All the following are anti-vitamins except
A:-Linetin
B:-Tyramine
C:-Citral
D:-Avidin
Correct Answer:- Option-B
Question47:-The toxin responsible for Epidemic dropsy is
A:-Vicin
B:-Thio-oxazolidone
C:-Beta oxalyl amino alanine
D:-Sanguinarine
Correct Answer:- Option-D
Question48:-Which mineral deficiency is characterized by both hematological and neurological manifestations?
A:-Zinc
B:-Copper
C:-Selenium
D:-Molybdenum
Correct Answer:- Option-B
Question49:-Tetany is seen in
A:-Vitamin D deficiency
B:-Hypoalbuminemia
C:-Metabolic alkalosis
D:-None of the above
Correct Answer:- Option-C
Question50:-Which of the following enzyme do NOT require biotin for its action?
A:-Aminoimidazole ribonucleotide carboxylase
B:-Pyruvate carboxylase
C:-Acetyl CoA carboxylase
D:-Propionyl CoA carboxylase
Correct Answer:- Option-A
Question51:-Select the technique that is used for studying gene expression in a tissue
A:-Multiplex PCR
B:-DNA finger printing
C:-Microarray technique
D:-Southern blot technique
Correct Answer:- Option-C
Question52:-Which of the following statement is false regarding innate immunity?
A:-First line of defense against infection
B:-Lymphocytes play a major role
C:-Is less specific
D:-Innate immune responses are uniform in all members of a species
Correct Answer:- Option-B
Question53:-The autoimmune disease where tissue destruction is mediated directly by T cells is
A:-Rheumatoid arthritis
B:-Hashimoto’s thyroiditis
C:-Autoimmune hemolytic anemia
D:-Goodpasture’s syndrome
Correct Answer:-Question Cancelled
Question54:-Maternal serum Alpha feto protein level is decreased in
A:-Anencephaly
B:-Down syndrome
C:-Cystic hygroma
D:-Meckel syndrome
Correct Answer:- Option-B
Question55:-Which of the following is an RNA directed site specific nuclease?
A:-CRISPER-Cas9
B:-CRE recombinase
C:-S1 nuclease
D:-Flp recombinase
Correct Answer:- Option-A
Question56:-Which of the following is a sulfur containing vitamin?
A:-Thiamine
B:-Riboflavin
C:-Pantothenic acid
D:-Folic acid
Correct Answer:- Option-A
Question57:-All the following features are true regarding kwashiorkor EXCEPT
A:-Age of onset is 1-5 years
B:-Serum albumin is less than 2gm/dL
C:-Dry and atrophic skin
D:-Serum cortisol is increased
Correct Answer:-Question Cancelled
Question58:-Which of the following vector carries the risk of insertional mutagenesis when used in gene therapy?
A:-Retroviruses
B:-Adenoviruses
C:-Plasmids
D:-Herpes simplex viruses
Correct Answer:- Option-A
Question59:-Simultaneous analysis of multiple metabolites in the same blood spot is referred to as
A:-Second-Tier testing
B:-Multiplex analysis
C:-Tandem Mass spectrometry
D:-Newborn screening
Correct Answer:-Question Cancelled
Question60:-The test that is done to assess vitamin B12 absorption is
A:-Serum methylmalonic acid assay
B:-Plasma homocysteine assay
C:-Schilling test
D:-Deoxyuridine suppression test
Correct Answer:- Option-C
Question61:-Aspirin is used in the treatment of myocardial infarction since it inhibits platelet aggregation by inhibiting the synthesis of
A:-Prostacyclin
B:-Thromboxane
C:-Leukotriene
D:-Prostaglandin E
Correct Answer:- Option-B
Question62:-Refsum disease characterized by vision loss, anosmia ataxia and polyneuropathy is due to defect in
A:-Fatty acid oxidation
B:-Fatty acid synthesis
C:-Glycogenolysis
D:-Glycogenesis
Correct Answer:- Option-A
Question63:-The assay of 5 Hydroxy indole acetic acid in urine is useful in the diagnosis of
A:-Pheochromocytoma
B:-Von Gierke’s disease
C:-Carcinoid syndrome
D:-Acute intermittent porphyria
Correct Answer:- Option-C
Question64:-Pellagra like symptoms is commonly seen in disorders associated with the defect in the metabolism of
A:-Arginine
B:-Glycine
C:-Cysteine
D:-Tryptophan
Correct Answer:- Option-D
Question65:-The rate limiting enzymes of gluconeogenesis are
(i) Pyruvate carboxylase
(ii) Pyruvate dehydrogenase
(iii) Glucose-6-phosphatase
(iv) Phosphofructokinase
A:-(i) and (ii)
B:-(ii) and (iv)
C:-(i) and (iii)
D:-(ii) and (iii)
Correct Answer:- Option-C
Question66:-The type of porphyria associated with the defect in the enzyme uroporphyrinogen decarboxylase is
A:-Porphyria cutanea tarda
B:-Congenital erythropoietic porphyria
C:-Erythropoietic protoporphyria
D:-Acute intermittent porphyria
Correct Answer:- Option-A
Question67:-Ochronosis, a condition where black pigments are deposited in cartilage is due to deficiency of the enzyme
A:-Tyrosinase
B:-Homogentisic acid oxidase
C:-Fumarylacetoacetate hydrolase
D:-Methyl malonyl CoA mutase
Correct Answer:- Option-B
Question68:-All of the following are types of type II detoxification reactions except
A:-Oxidation
B:-Conjugation
C:-Acetylation
D:-Sulfation
Correct Answer:- Option-A
Question69:-Which of the following is not a diagnostic-criteria for a metabolic syndrome?
A:-Fasting glucose- more than 100 mg/dl
B:-Triglyceride – more than 150 mg/dl
C:-HDL-cholesterol – more than 50 mg/dl
D:-Blood pressure – more than 130/85 mm Hg
Correct Answer:- Option-C
Question70:-The liver function test parameters for a patient admitted with jaundice is as follows serum total bilirubin – 10 mg/dl, Direct bilirubin – 9.5 mg/dl. Urine: Bile salts and bile pigments – positive which of the following enzymes is increased in this patient?
A:-Amylase
B:-Alkaline phosphatase
C:-Lactate dehydrogenase
D:-Creatine kinase
Correct Answer:- Option-B
Question71:-Urea reduction ration is used to
A:-Assess the adequacy of hemodialysis
B:-Diagnosis of nephrotic syndrome
C:-Analyze the toxicity of nephrotoxic drugs
D:-Classify different stages of renal failure
Correct Answer:- Option-A
Question72:-The lab data of a patient’s serum sample were as follows: Total Cholesterol: 300 mg/dL, HDL cholesterol: 40 mg/dl and Triglycerides : 200 mg/dL The calculated LDL cholesterol level for the patient is
A:-100 mg/dL
B:-60 mg/dL
C:-220 mg/dL
D:-40 mg/dL
Correct Answer:- Option-C
Question73:-All of the following enzymes are involved in substrate level phosphorylation except
A:-Pyruvate kinase
B:-Phosphoglycerate kinase
C:-Succinate thiokinase
D:-Phosphoenolpyruvate carboxykinase
Correct Answer:- Option-D
Question74:-Regan isoenzymes is increased in
A:-Carcinoma of lung
B:-Chronic myeloid leukemia
C:-Metastatic carcinoma of prostate
D:-Choriocarcinoma
Correct Answer:- Option-A
Question75:-Ezetimibe reduces blood cholesterol levels by
A:-Inhibiting HMG-CoA reductase
B:-Inhibiting absorption
C:-Activating lipoprotein lipase
D:-Inhibiting lipolysis
Correct Answer:- Option-B
Question76:-Fatty liver can be prevented by
A:-Methionine
B:-Aspartate
C:-Arginine
D:-Lysine
Correct Answer:- Option-A
Question77:-Which of the following statement in NOT TRUE about Levey-Jennings chart?
A:-QC sample should be analyzed for 20 days
B:-Mean and standard deviation are needed to plot the chart
C:-Patient results can be reported when a single control value exceeds the QC limit
D:-12s rule has been widely used by the laboratories
Correct Answer:-Question Cancelled
Question78:-All of the following are types of preanalyltical variables except
A:-Patient identification
B:-Transcription errors
C:-Specimen collection
D:-Water quality
Correct Answer:- Option-D
Question79:-Triple test, commonly used in maternal screening in second trimester include all of the following markers except
A:-Human chorionic gonadotrophin
B:-Unconjugated Estriol
C:-Progesterone
D:-Alpha fetoprotein
Correct Answer:- Option-C
Question80:-Flipped pattern of Lactate dehydrogenase isoenzyme is seen in
A:-Myocardial infarction
B:-Renal failure
C:-Hepatitis
D:-Addison disease
Correct Answer:- Option-A
Question81:-For Covid 19 RT-PCR test mineral used in RTPCR process
A:-Mn
B:-Mg
C:-Zn
D:-Cr
Correct Answer:- Option-B
Question82:-The VLDL, LD: levels increase in blood due to high intake of
A:-Glucose diet
B:-Fructose diet
C:-lactose diet
D:-Starch diet
Correct Answer:- Option-B
Question83:-The elementary composition of the human body (dry weight basis) in %
A:-C 50%, O 20%, H 10%, N 8.5%
B:-C 40%, O 30%, H 8%, N 7%
C:-C 50%, O 10%, H 20%, N 6%
D:-C 50%, O 10%, H 20%, N 12%
Correct Answer:-Question Cancelled
Question84:-Normal chemical composition for a man weighting 65 kg
A:-Protein 17% Fat 13% Carbon 1.5% Water 61.6% Minerals 6.1%
B:-Protein 15% Fat 10% Carbon 2.5% Water 70% Minerals 7%
C:-Protein 12% Fat 15% Carbon 1.5% Water 6.6% Minerals 6.1%
D:-None
Correct Answer:- Option-A
Question85:-A 54-year male presents with acute abdominal pain, no skin photosensitization, large amount of aminolevulinic acid (ALA) and porphobilinogen (PBG) in urine, and symptoms exacerbated by steroids and several other drugs. Which of the following best describes the conditions?
A:-Porphyria cutanea tarda
B:-Acute intermittent porphyria
C:-Porphyria variegata
D:-Hepatic porphyria
Correct Answer:- Option-B
Question86:-A 10-year old boy develops sever diarrhoea while travelling to India. the laboratory blood investigation shows arterial blood pH 7.25; partial pressure of carbon dioxide 24mm Hg; bicarbinate 10 mEq/L and normal anion gap. Which of the following is correct diagnosis?
A:-Metabolic acidosis
B:-Metabolic alkalosis
C:-Respiratory acidosis
D:-Respiratory alkalosis
Correct Answer:- Option-A
Question87:-A 40-year old woman presented with history of fatigue, easy bruising, bleeding from gums while brushing her teeth and a diffuse rash involving her extremities and trunk that had been present for several days. The deficiency of which of the following is because of her symptoms?
A:-Niacin
B:-Pyridoxine
C:-Pantothenic Acid
D:-Ascorbic acid
Correct Answer:- Option-D
Question88:-A 29-year old man comes to his doctor with symptoms of HIV infection. The doctor orders several confirmatory tests, for one of them a protein sample is taken and is run on electrophoretic gel, causing it to separate by size and charge. The protein was then transferred to a membrane, and labelled antibody is added to allow visualization of this protein.
Which of the following tests in described here?
A:-Southern blot
B:-Western blot
C:-Northern blot
D:-South western blot
Correct Answer:- Option-B
Question89:-In cancer patients who have been continuously receiving methotrexate, the target cells of tumor with time become sensitive to his drug. In this case, most commonly gene amplification of the following enzyme is observed:
A:-Dihydrofolate reductase
B:-Thiaminase
C:-Deaminase
D:-Thioredoxin reductase
Correct Answer:- Option-A
Question90:-A doctor administered allopurinol to a 26-year old young man with symptoms of gout. Which of the following pharmacological action of allopurinol ensures therapeutic effect?
A:-Inhibiting uric acid synthesis
B:-Increasing uric acid excretion
C:-Inhibiting leucocyte migration in the joints
D:-General anti-inflammatory effect
Correct Answer:- Option-A
Question91:-A 56-year old man was operated on prostate cancer, three months later he underwent a course of radiotherapy and chemotherapy. .The complex of medicinal preparations prescribed to the patient included 5-fluoro-deoxyuridine, which is a thymidylate synthase inhibitor, Which of the following biomolecule’s synthesis is blocked by the drug?
A:-DNA
B:-mRNA
C:-rRNA
D:-tRNA
Correct Answer:- Option-A
Question92:-A patient with radiation therapy because of brain tumor was prescribed vitamin E and a micro element with antioxidant function. Which of the following can be used for this purpose?
A:-Fluorine
B:-Selenium
C:-Iron
D:-Iodine
Correct Answer:- Option-B
Question93:-A 3-year old child comes to the hospital with history of biting his lips and fingers, involuntary movements of upper limb and mental retardation. he has a younger healthy sister. Lab investigations showed high serum uric acid. Which of the following is the most likely diagnosis?
A:-Adenine deaminase
B:-LeschNyhah Syndrome
C:-Orotic aciduria
D:-Fragile X syndrome
Correct Answer:- Option-B
Question94:-A 7-year boy comes to the hospital with yellow discoloration of eyes, decreased apetite and general malaise for last 1 week. She has been passing dark colored urine and
high colored faces for the same duration. Lab investigations showed serum total bilirubin 4.5 mg%, direct bilirubin 1.2 mg%, indirect faeces 3.3 mg%. liver enzymes are normal. Which
of the following is the most likely cause of jaundiced in this patient?
A:-Obtrusive jaundice
B:-Physiological jaundice
C:-Hepatic jaundice
D:-Hemolytic jaundice
Correct Answer:-Question Cancelled
Question95:-A 20-year old male visits dermatology OPD with complaints of increased sensitivity to sunlight causing blistering and crusting of skin only few minutes of sun exposure.
Delayed growth and intellectual disability were noticed. Skin biopsy was taken. Which of the following is the most likely diagnosis?
A:-Xeroderma pigmentosum
B:-Pellagra
C:-Vitamin A deficiency
D:-Zinc deficiency
Correct Answer:- Option-A
Question96:-a 20-year old male patient presented with severe abdominal pain with difficulty in fine motor tasks. Lab investigation showed elevated liver enzymes and increased urinary calcium and phosphate Opthalamological examination revealed Kayser Fleischer ring in the cornea. Which of the following is most likely cause of the presenting symptoms in this case?
A:-Iron deficiency
B:-Copper excess
C:-Selenium deficiency
D:-Zinc excess
Correct Answer:- Option-B
Question97:-A patient is undergoing radiation therapy because of breast cancer. This resulted in increased lipid peroxidation processes. In the course of which active forms of oxygen including superoxide anion radical are formed in the human body. Which of the following enzymes inactivates this anion?
A:-Superoxide dismutase
B:-Glutathione reductase
C:-Peroxidase
D:-Catalase
Correct Answer:- Option-A
Question98:-The Anfinsen’s dogma states that
A:-Secondary structure directs in vivo folding
B:-Primary structure directs in vivo folding
C:-Tertiary structure directs in vivo folding
D:-Quaternary structure directs in vivo folding
Correct Answer:- Option-B
Question99:-The maximum buffering capacity occurs at
A:-±1 pH unit on either side of pKa
B:-±2 pH unit of the other side of pKa
C:-Neutral pH
D:-None of the above
Correct Answer:- Option-A
Question100:-The defective DNA base excision repair (BER) is found in
A:-Xeroderma pigmentosm
B:-Bloom syndrome
C:-Mutyh-associated polyposis (MAP)
D:-Heredietary nonpolyposis colorectal cancer (HNPCC)
Correct Answer:- Option-C
